Jan 01, 2016
DOI: 10.1016/j.jsha.2015.05.003
Published in: Journal of the Saudi Heart Association
Publisher: Journal of the Saudi Heart Association
‘The can of un-coagulated blood lying on the floor of Link’s laboratory was to change the course of history, and little did Link know what the long-term implications would be’’[1]. In 1941, the Wisconsin Alumni Research Fund (WARF) scientist Karl Paul Link and his senior student Wilhelm Schoeffel could never have imagined that their research would live longer than 73 years. Link named the substance after the organization that supported his research and the name warfarin was created (Fig. 1). In the 1950s, warfarin was used as an anticoagulant for victims of heart attacks and strokes. It gained fame when it was used to treat President Dwight D. Eisenhower after his 1955 coronary event while in office [1]. The historical narrative of warfarin starts with a mysterious hemorrhagic disease (sweet clover disease) of cattle to the development of a rat poison (rodenticide), which later became one of the most commonly
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