Biography
I started my academic career after graduating from faculty of pharmacy, Zagazig University, Egypt in 2011 working as demonstrator of Medicinal chemistry. I started my research training in school of pharmacy, Cardiff University, UK for one year. Then I got my master's degree in 2016 also from Zagazig University. Afterwards, I went back to Cardiff to get my PhD in Medicinal Chemistry, which was achieved in 2021. Thereafter, I started teaching Medicinal chemistry and related courses such as drug design before joining AAU in August 2024. During my 13 years research journey till now, I gained expertise in the field of medicinal chemistry and drug discovery which was reflected in a number of quality publications in reputable journals.
Education
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Ph.D. Medicinal Chemistry, School of Pharmacy and pharmaceutical sciences, Cardiff University, Cardiff, UK
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Master's degree (M.Sc.) in pharmaceutical sciences, Zagazig University, Egypt
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Bachelor (B.Sc.) in Pharmaceutical sciences, Zagazig University, Egypt
Research Interests
My research interest lies in the field of Medicinal Chemistry. Some of the current work and future ideas that are being executed can be summarised as follows:
- Multi targeting of biological targets in the same or different biochemical pathways involved in cancer can offer alternative therapeutic approaches to overcome drug resistance (e.g., Dual targeting of aromatase and sulfatase enzymes in breast cancer).
- Antimicrobial resistance is driving the urge of finding novel microbial targets that could be crucial for the bacterial survival and welfare (e.g., Aminoacyl t-RNA synthetase inhibitors).
- Repurposing of currently available drugs in the market through screening to find promising drugs that can act as anti-biofilm or anti-quorum sensing to help in the fight against multi-drug resistant bacteria.
Selected Publications
- Gad, A.I., El-Ganiny, A.M., Eissa, A.G., Noureldin, N.A. and Nazeih, S.I., 2024. Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa. The Journal of Antibiotics, pp.1-12.
- Elbaramawi, S.S.; Eissa, A.G.; Noureldin, N.A.; Simons, C., 2023. Exploring Proteus mirabilis Methionine tRNA Synthetase Active Site: Homology Model Construction, Molecular Dynamics, Pharmacophore and Docking Validation. Pharmaceuticals, 16, 1263.
- Eissa, A.G., Powell, L.E., Gee, J., Foster, P.A. and Simons, C., 2023. Pyridine based dual binding site aromatase (CYP19A1) inhibitors. RSC Medicinal Chemistry, 14(2), pp.356-366.
- El-Kalyoubi, S., Elbaramawi, S.S., Eissa, A.G., Al-Ageeli, E., Hobani, Y.H., El-Sharkawy, A.A., Mohamed, H.T., Al-Karmalawy, A.A. and Abulkhair, H.S., 2023. Design and synthesis of novel uracil-linked Schiff bases as dual histone deacetylase type II/topoisomerase type I inhibitors with apoptotic potential. Future Medicinal Chemistry, 15(11), pp.937-958.
- Elfaky, M.A., Elbaramawi, S.S., Eissa, A.G., Ibrahim, T.S., Khafagy, E.S., Ali, M.A. and Hegazy, W.A., 2023. Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria. Applied Microbiology and Biotechnology, pp.1-16.
- Eissa, A. G., Barrow, D., Gee, J., Powell, L. E., Foster, P. A., & Simons, C. 2022. 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors. European Journal of Medicinal Chemistry, 114569.
- Thabit, A.K., Eljaaly, K., Zawawi, A., Ibrahim, T.S., Eissa, A.G., Elbaramawi, S.S., Hegazy, W.A. and Elfaky, M.A., 2022. Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens. Biology, 11(9), p.1349.
- Thabit, A.K., Eljaaly, K., Zawawi, A., Ibrahim, T.S., Eissa, A.G., Elbaramawi, S.S., Hegazy, W.A. and Elfaky, M.A., 2022. Silencing of Salmonella typhimurium Pathogenesis: Atenolol Acquires Efficient Anti-Virulence Activities. Microorganisms, 10(10), p.1976.
- Cavalu, S., Elbaramawi, S.S., Eissa, A.G., Radwan, M.F., S. Ibrahim, T., Khafagy, E.S., Lopes, B.S., Ali, M.A., Hegazy, W.A. and Elfaky, M.A., 2022. Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol against Gram-Negative Bacterial Pathogens. International Journal of Molecular Sciences, 23(21), p.13088.
- Eissa, A. G., Blaxland, J. A., Williams, R. O., Metwally, K. A., El-Adl, S. M., Lashine, E. S. M., ... & Simons, C. 2016. Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1694-1697.
Professional Experience
- Ph.D. Thesis: “4th Generation aromatase inhibitors for the treatment of breast cancer: design, synthesis, biochemical and molecular biology studies” (2021).
- M.Sc. Thesis: “Exploring aminoacyl-tRNA synthetase inhibitors as novel anti-infective drugs” (2016).
- My research experience includes the design and synthesis of small molecules. During my PhD studies and afterwards, I have been involved in the drug discovery process starting from the design and computer-aided drug design (molecular docking, modelling and molecular dynamics and other computational processes), then the development of synthetic schemes for small molecules. I have extensive experience in the synthesis of small molecules and their modifications with complete analysis for the products (NMR, HPLC, and interpretation of MS). I have also been involved during my PhD study in cell culture work.
Teaching Courses
- Medicinal Chemistry (B.Sc.)
- Organic Chemistry (B.Sc.)
- Advanced pharmaceutical chemistry (M.Sc.)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.
This person’s work contributes towards the following SDG(s):
