Staff

  • Kareem Abdou

Kareem Abdou

Assistant Professor

Al Ain Campus

Biography

My academic journey began at Cairo University, where I served as a teaching assistant after graduating from the Faculty of Pharmacy in 2010. In 2014, I got the chance to pursue my PhD study at University of Toyama in Japan where I got my PhD in 2018. After that I got postdoctoral position for one year, then I was promoted to be an assistant professor of cognitive neuroscience in 2019. In 2022, I returned to work at Cairo University before joining Al-Ain University in 2024 at the rank of assistant professor.

My interdisciplinary research connects Cognitive Neuroscience, Pharmacology, Biochemistry and Molecular Genetics by using cutting edge technologies to understand the nature of human cognition and behavior. I have outstanding publications in top tier journals including Science, Nature Communications, PNAS and others. My publications were featured in several news articles and TV shows in Japan, in addition to citations from a Nobel prize laureate (Prof. Eric Kandel) in his recent publications. Since my innovative research opens up a new horizon in the neuroscience field, I received two research grants from Japan Society for the Promotion of Science (JSPS) in 2019 and 2022.

Education

  • Ph.D. in Medical Sciences, Faculty of Medicine, University of Toyama, Toyama, Japan
  • Bachelor of Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Research Interests

My research interests span a broad spectrum of neurological disorders, focusing on elucidating their biochemical underpinnings and identifying novel diagnostic and therapeutic approaches.

My research aims to:

1- Unravel the biochemical mechanisms that underlie various neurological disorders, including neurodegenerative diseases, neurodevelopmental disorders, and psychiatric conditions.

2- Explore cutting-edge techniques to accurately diagnose neurological disorders at early stages.

3- Discover potential therapeutic targets and develop innovative approaches to treat neurological disorders.

Selected Publications

2024

Discovery of novel thiazole derivatives containing pyrazole scaffold as PPAR-γ Agonists, α-Glucosidase, α-Amylase and COX-2 inhibitors; Design, synthesis and in silico study

WAA Fadaly, A Elshewy, MTM Nemr, K Abdou, AM Sayed, NM Kahk

Bioorganic Chemistry (2024), 152, 107760

 

Prefrontal coding of learned and inferred knowledge during REM and NREM sleep

K Abdou, M Nomoto, MH Aly, AZ Ibrahim, K Choko, R Okubo-Suzuki, S Muramatsu, K Inokuchi

Nature Communications (2024), 15 (1), 4566

 

Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis, biological Evaluation and docking studies

N Reda, KO Mohamed, K Abdou, AA Helwa, A Elshewy

Bioorganic Chemistry (2024), 145, 107185

 

2022

A short-term memory trace persists for days in the mouse hippocampus

ME Wally, M Nomoto, K Abdou, E Murayama, K Inokuchi

Communications Biology (2022), 5 (1), 1168

 

Selective engram coreactivation in idling brain inspires implicit learning

MH Aly*, K Abdou*, R Okubo-Suzuki, M Nomoto, K Inokuchi

Proceedings of the National Academy of Sciences (2022), 119 (32), e2201578119

 

2018

Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress

R Inoue, K Abdou, A Hayashi-Tanaka, S Muramatsu, K Mino, K Inokuchi, H Mori

Elife (2018), 7, e34135

 

Synapse-specific representation of the identity of overlapping memory engrams

K Abdou, M Shehata, K Choko, H Nishizono, M Matsuo, S Muramatsu, K Inokuchi

Science (2018), 360 (6394), 1227-1231

 

Autophagy enhances memory erasure through synaptic destabilization

M Shehata*, K Abdou*, K Choko, M Matsuo, H Nishizono, K Inokuchi

Journal of Neuroscience (2018), 38 (15), 3809-3822

Teaching Courses

1- Pharmacology (BSc.)

2- Pharmacogenetics (BSc.)

3- Phytotherapy (BSc.)

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.

This person’s work contributes towards the following SDG(s):

Memberships

1- Japan Neuroscience Society (JNS), Japan.

2- Society For Neuroscience (SFN), USA.

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