Abu Dhabi Campus
My research interest lies in the field of computer-aided drug design where I focus in three main areas:
(1) Designing and discovery of new inhibitors for different drug targets using structure-based and ligand-based approaches;
(2) Assessing protein structures in terms of pocket protein-ligand interactions and druggability:
(3) Investigating the aggregation molecular behavior of small organic molecules using molecular dynamics simulations.
Hasan S, Kayed K, Ghemrawi R, ... Atatreh N, Ghattas MA*. Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors. Molecules, 2023, 28(7), 3000
Kharaba Z, AlAhmad MM, Ahmed Elnour A, ... Abumweis S, Ghattas, MA. Are we ready yet for digital transformation? Virtual versus on-campus OSCE as assessment tools in pharmacy education. A randomized controlled head-to-head comparative assessment. Saudi Pharmaceutical Journal, 2023, 31(3), 359–369.
Salem AA, El Haty, IA, Ghattas MA. GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA. PLoS ONE, 2022, 17(12 December), e0277963
Mahgoub RE, Mohamed FE, Alzyoud L, ...Atatreh N, Ghattas MA*. The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation Molecules, 2022, 27(19), 6710.
Alzyoud L, Ghattas MA*, Atatreh N. Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents. Drug Design, Development and Therapy. 2022, 16, 2463–2478.
Alzyoud L, Bryce RA, Al Sorkhy M, Atatreh N, Ghattas MA*. Structure-based assessment and druggability classification of protein-protein interaction sites. Scientific Reports. 2022, 12(1), 7975
Ghemrawi R, Khair M, Hasan S, Aldulaymi R, AlNeyadi SS, Atatreh N, Ghattas MA*. The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines. International journal of molecular sciences 23 (8), 4468 https://doi.org/10.3390/ijms23084468
Al Neyadi SS, Adem A, Amer N, Ghattas MA, Atatreh N, Salem AA, Abdou IM. Activation of the GLP-1 receptor by chloropyrimidine derivatives. Results in Chemistry. 3, 2021, 100222. https://doi.org/10.1016/j.rechem.2021.100222
Ramadan A, Hasan S, Jamal S, Moumen I, Atatreh N, Ghattas MA*. Development of a novel filtered-based pharmacophore for the identification of human equilibrative nucleoside transporter 1 inhibitors. Jordan Journal of Pharmaceutical Sciences. 14, 3, 293-306, 2021.
Atatreh N, Hasan S, Ali BR, Ghattas MA*. Computer-aided approaches reveal Trihydroxychroman and Pyrazolone derivatives as potential inhibitors of SARS-COV-2 virus main protease. Acta Pharmaceutica, Volume 71, Pages 325-333, 2021. https://doi.org/10.2478/acph-2021-0040
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.
This person’s work contributes towards the following SDG(s):
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