Biography

More than 17 years of experience in research and teaching in the field of development of dosage forms, especially nanomedicines and their interactions with the biological system for the treatment of chronic inflammatory diseases.
Design and validate the cell co-culture model for the treatment of lung cancer. Experience in performing various in vitro and in vivo techniques including cell culturing, cell viability assay, western blotting, ELISA and PCR. You will also work with flow cytometry and confocal microscope. Moderate experience working with atomic force microscopy, X-ray diffraction, FT-IR and microcalorimetry.
Develop the physiologically based pharmacokinetic model (PBPK) for a few drugs. Interoperate the ADMET properties and the pharmacokinetic compartment properties of drugs. Simulate the possible drug-drug interactions and validate the plasma concentration-time curve using multiple doses and dosage forms.

 

Education

• Doctor of Philosophy (Ph.D.) (Pharmaceutical Sciences) University of Alberta, Edmonton, Alberta, Canada.
• Master of Philosophy, (Pharmaceutics) The Islamia University of Bahawalpur, Pakistan.
• Bachelor of Pharmacy, The Islamia University of Bahawalpur, Pakistan.

Research Interests

• Synthesis and In Vitro and In Vivo Characterization of Nanoparticles.
• Target Drug Delivery of Nanoparticles and its Impact on Cell Models.
• Developing Co-Culture models for Cancer Cells and Macrophages.
• PBPK/PD modeling, Drug Drug Interaction, Population PK and IVIVC using Gastroplus Simulation Software.

Selected Publications

• Najia Rahim, Muhammad Sarfraz, Abubakar Bello, Syed Baqir Shyum Naqvi. Dosage Optimization Using Physiologically Based Pharmacokinetic Modeling for Pediatric Patients with Renal Impairment: A Case Study of Meropenem.  AAPS PharmSciTech. 26:38 .16 January 2025.   https://doi.org/10.1208/s12249-024-03026-y
• Wajeeha Khalid, Afeefa Aslam, Nadeem Ahmed, Muhammad Sarfraz, Jawad Akbar Khan, Sabeeh Mohsin, Muhammad Shahid Riaz Rajoka, Imran Nazir, Muhammad Imran Amirzada. Human Plasma-Derived Exosomes: A Promising Carrier System for the Delivery of Hydroxyurea to Combat Breast Cancer.  AAPS PharmSciTech. 26:42 .22 January 2025 . https://doi.org/10.1208/s12249-024-03028-w
• Muhammad Sarfraz, Muhammad Khurram Waqas, Hamid Saeed Shah, Faisal Usman, Tariq Ismail, Sumera Zaib, Riffat Khan, Zobia Jawad, Memona Ishtiaq, Yasser Shahzad. Hyaluronic acid functionalized chitosan nanoparticles for the delivery of ellagic acid to breast cancer cells: Fabrication, characterization and pharmacological assessment.  J Drug Deliv Sci Technol  102 Part B,106418.  December, 2024.  106418.  https://doi.org/10.1016/j.jddst.2024.106418
• Mah Jabeen Akbar, Hafiz Shoaib Sarwar, Muhammad Sarfraz, Aimon Qureshi, Aamir Jalil, Fareeha Anwar, Muhammad Zaman, Muhammad Farhan Sohail, Raimar Löbenberg. Macrophage targeted nanocarriers containing methotrexate against arthritis.J Drug Deliv Sci Technol. 102 Part A, 106319. December 2024.   https://doi.org/10.1016/j.jddst.2024.106319
• Hina Shoukat, Fahad Pervaiz, Sadia Rehman, Kifayat Ullah Khan, Muhammad Sarfraz, Sobia Noreen, Muhammad Rafi Raza, Hassan Mahmood. Enhancing solubility and oral bioavailability of rosuvastatin through interpenetrating polymer network (IPN) nanogels: Fabrication, characterization, and in-vivo efficacy assessment,J Drug Deliv Sci Technol 98, 105866. September 2024. https://doi.org/10.1016/j.jsps.2024.102096
• Fahimeh Zahednezhad, Saeideh Allahyari, Muhammad Sarfraz, Parvin Zakeri-Milani, Mohammad Feyzizadeh & Hadi Valizadeh. Liposomal drug delivery systems for organ-specific cancer targeting: early promises, subsequent problems, and recent breakthroughs. Expert Opinion on Drug Delivery. 21(09), P: 1363-1384, August 2024.  https://doi.org/10.1080/17425247.2024.23946
•  Muqeeza Arshad, Hafiz Shoaib Sarwar, Muhammad Sarfraz, Aamir Jalil, Yousef A Bin Jardan, Umer Farooq, Muhammad Farhan Sohail. Cholic Acid-Grafted Thiolated Chitosan-Enveloped Nanoliposomes for Enhanced Oral Bioavailability of Azathioprine: In Vitro and In Vivo Evaluation. ACS omega. 9(30), P: 32807-32816, July2024.  https://doi.org/10.1021/acsomega.4c03369
• Farid Mostafaei, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Muhammad Sarfraz, Mahdieh Abdi, Shukoofeh Torabi, Behzad Baradaran, Massoud Vosough, Parvin Zakeri-Milani. Enhanced intracellular accumulation and cytotoxicity of bortezomib against liver cancer cells using N-stearyl lactobionamide surface modified solid lipid nanoparticles. Int.J.Pharm. 649, P: 123635, January2024.  https://doi.org/10.1016/j.ijpharm.2023.123635
• Muhammad Sarfraz, M Afroz Bakht, Mohammed Sanad Alshammari, Mohammad Alrofaidi, Abdullah R Alzahrani, Lina Eltaib, Syed Mohammed Basheeruddin Asdaq, Faris F Aba Alkhayl, Abida, Mohd Imran. Beyond traditional medications: exploring novel and potential inhibitors of trypanothione reductase (LmTr) of Leishmania parasites. J. Biomol. Struct. Dyn. December2023.  https://doi.org/10.1080/07391102.2023.2300062
• Muhammad Sarfraz, Kanwal Shabbir, Qazi Adnan, Haji Muhammad Shoaib Khan, Jafir Hussain Shirazi, Hamna Sabir, Nimrah Mehmood, Yousef A Bin Jardan, Kifayat Ullah Khan, Abdul Basit. Fabrication, organoleptic evaluation and in vitro characterization of cream loaded with Carica papaya seed extract. J.Cosmet. Dermatol. December2023.  https://doi.org/10.1111/jocd.16066
• Muhammad Sarfraz*, Ume Ruqia Tulain^,, Alia Erum, Nadia Shamshad Malik, Arshad Mahmood, Sumaira, Sidra Aslam, Mansur Abdullah Sandhu and Muhammad Tayyab Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery In Vitro and in Vivo Evaluation. Pharmaceutics Vol 15, 2445, P-1  21 October2023.  https://doi.org/10.3390/pharmaceutics15102445
• Muhammad Sarfraz*, Abida Khan, Gaber El-Saber Batiha, Muhammad Furqan Akhtar, Ammara Saleem, Basiru Olaitan Ajiboye, Mehnaz Kamal, Abuzer Ali, Nawaf M. Alotaibi , Shams Aaghaz, Muhammad Irfan Siddique and Mohd Imran. Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy. Cancers Vol 15, 4194, P-1-21 August 2023. https://doi.org/10.3390/cancers15164194
• Muhammad Sarfraz, Rabia Iqbal, Kifayat Ullah Khan, Muhammad Usman Minhas. Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers. J. Funct. BIomater. 13, 295, P:2-21, December,2022. https://doi.org/10.3390/jfb13040295
•  Mohammad Feyzizadeh, Ashkan Barfar, Zeinab Nouri, Muhammad Sarfraz, Parvin Zakeri-Milani, Hadi Valizadeh. Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discovery. Expert Opin. Drug Discov. Page:1-15, September 2022.  https://doi.org/10.1080/17460441.2022.2112666
• Muhammad Sarfraz, Shaista Qamar, Masood Ur Rehman, Muhammad Azam Tahir, Muhammad Ijaz, Anam Ahsan, Mulazim Hussain Asim, Imran Nazir. Nano-Formulation Based Intravesical Drug Delivery Systems: An Overview of Versatile Approaches to Improve Urinary Bladder Diseases. Pharmaceutics Vol: 14 (9) 1909. September 2022.  https://doi.org/10.3390/pharmaceutics14091909
• Solmaz Mojarad-Jabali, Somayeh Mahdinloo, Masoud Farshbaf, Muhammad Sarfraz, Yousef Fatahi, Fatemeh Atyabi, Hadi Valizadeh. Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer. Expert Opin. Drug Deliv. Page1-21 July2022.  https://doi.org/10.1080/17425247.2022.2083106
• Fahimeh Zahednezhad, Javid Shahbazi Mojarrad, Parvin Zakeri-Milani, Behzad Baradaran, Mohammad Mahmoudian, Muhammad Sarfraz & Hadi Valizadeh. Surface modification with cholesteryl acetyl carnitine, a novel cationic agent, elevates cancer cell uptake of the PEGylated liposomes. Int. J. Pharm. Vol 609, 121148, November 2021.  https://doi.org/10.1016/j.ijpharm.2021.121148

 

 

Teaching Courses

• Pharmaceutics -I (BSc.)
• Biopharmaceutics and Pharmacokinetic (BSc.)
• Adavanced Drug Delivery (MSc.)

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.

This person’s work contributes towards the following SDG(s):

 

Memberships

• Pharmacy Council of Pakistan.
• Canadian Society of Pharmaceutical Sciences (CSPS), Canada.
• American Association Pharmaceutical Scientist. (AAPS) USA.