Mosab Arafat, Ph.D

Assistant Professor

Al Ain Campus

+971 3 7024870

mosab.arafat@aau.ac.ae

Education

Ph.D. Nanomedicines, University of Otago, School of Pharmacy, New Zealand

MSc. Pharmaceutics, University Science Malaysia, School of Pharmaceutical sciences, Malaysia

B.Pharm. Faculty of Pharmacy, University of Karachi, Pakistan

Research Interests

Nanoparticle formulation of drugs and delivery of bioactive molecules for human. Development, preparation, characterization and stability evaluation of nano-colloidal drug delivery systems (Bilosomes, Liposomes & Niosomes). In vivo & in vitro evaluation of drug molecules loaded in nano-particles using animals/humans. Development of analytical methods for drug molecules and metabolic studies using HPLC and LC-MS.

Selected Publications

  1. Al Hanbali O,  Khan H, Sarfraz MMosab Arafat. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharm 2019; 69 (1):1 - 19."Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society"

  2. Khalid N, Sarfraz M,  Mosab Arafat,  Akhtar M, Löebenberg R,  Rahman N. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Chemotherapeutic Agent VP-16 in Rats: A Nano Lipid Carrier for BCS Class IV Drugs. J Pharm Pharm Sci 2018; 21 (1):  398 - 408.   "Canadian Society for Pharmaceutical Sciences"
  3. Rehan M, Saqib A, Riaz T, Aziz H, Mosab Arafat, Nouman H. Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists.  PLoS ONE 2018;13 (9), e0203568.
  4. Al-Hanbali O, Hamed R, Mosab Arafat, Bakkour Y, Al-Matubsi H, Mansour R, Al-Bataineh Y, Aldhoun M, Sarfraz M, Dardas A. Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and poloxamer 188 polymer: An assessment on mechanism of drug release. Pak J Pharm Sci 2018; 31: 1 (Suppl), 245-252
  5. Kamal T, Sarfraz M, Mosab Arafat, Mikov M, Rahman N. Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil. Pak J Pharm Sci 2017; 30: 6 (Suppl), 2329-2336
  6. Mosab Arafat, Kirchhoefer C, Mikov M, Sarfraz M, Löbenberg M. Nanosized liposomes containing bile salt: a vesicular nanocarrier for enhancing oral bioavailability of BCS class III drug. J Pharm Pharm Sci 2017; 20: 305-318. DOI: 10.18433/J3CK88. "Canadian Society for Pharmaceutical Sciences"
  7. Mosab Arafat, Kirchhoefer C, Mikov M. Mixed Micelles Loaded with Bile Salt: An Approach to Enhance Intestinal Transport of the BCS Class III Drug Cefotaxime in Rats. European Journal of Drug Metabolism and Pharmacokinetics2016, 42:.1-11. DOI: 10.1007/s13318-016-0375-9
  8. Mosab Arafat, Ahmed Z, Arafat O. Comparison Between Generic Drugs and Brand Name Drugs From Bioequivalence and Thermoequivalence Prospective. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9 (6): 1-4.
  9. Mosab Arafat, The effect of intestinal bile on the stability of lipid-based vesicular system used as oral drug carriers. Glob Drugs Therap 2016 (2)1:1-2: DOI: 10.15761/GDT.1000109
  10. Mosab Arafat, Ahmed Z, Mikov M. Determination of Nifedipine in Rat Plasma Using HPLC-UV Detector: A Simple Method for Pharmacokinetics and Oral Bioavailability Studies. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8 (8): 98-102.
  11. Mosab Arafat. Approaches to Achieve An Oral Controlled Release Drug Delivery System Using Polymers: A Recent Review. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7 (7) 16-21.
  12. Mosab Arafat, Golocorbin-Kon S, Mikov M. The Measurement of Cefotaxime Sodium in Rat Plasma After Oral Administration: A Sensitive HPLC-UV Method. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7 (4) 343-346.
  13. Mosab Arafat. Simple HPLC Validated Method for Determination of Diltiazem Hydrochloride in Human. International Journal of Pharmacy and Pharmaceutical Sciences.2014; 6 (9) 213-216.
  14. Mosab Arafat, Salam A, Arafat O. The Association of Type 2 Diabetes with Obesity and Other factors: In Multinational Community. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6 (9) 257-260.
  15. Golocorbin-Kon S, Mikov M, Mosab Arafat, Lepojevic Z, Mikov I, Sahman-Zaimovic M, Tomic Z. Cefotaxime pharmacokinetics after oral application in the form of 3alpha, 7alpha-dihydroxy-12-keto-5-beta-cholanate micro-vesicles in rat. European Journal of Drug Metabolism and Pharmacokinetics 2009; 34 (1): 31-37. 

Conferences

  1.  Mosab Arafat, C. Kirchhoefer, Sarfraz M, Löbenberg R. Study the Effect of Physiological Fluid on Vesicles Membrane Stability of Liposomes containing Bile Salts using Calcein as a Marker for Vesicles Leakage. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 4-7, 2018. Washington DC, USA.
  2. Mosab Arafat, Kirchhoefer C, Mikov M.  Nano-Mixed Micelles: An Approach to Enhance the Oral Bioavailability of BCS Class III Drug.  14th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology. Apr 2018. Amsterdam, Netherland.
  3. Mosab Arafat, Kirchhoefer C, Mikov M, Sarfraz M, Löebenberg R. The enhancement of the poor oral bioavailability of cefotaxime sodium using nano-mixed micelles formulation. Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018. Toronto, Canada.
  4. Khalid N, Sarfraz M, Mosab Arafat, Akhtar M, Rahman N, Löebenberg R. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Etoposide in Rats.Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018. Toronto, Canada.
  5. Mosab Arafat,  Sarfraz M, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.
  6. Mosab Arafat. The application of nanotechnology on drug delivery systems. Nanotechnology and Materials ScienceWorld Congress and Expo, 13th – 15th April 2015, Dubai, UAE
  7. Mosab Arafat. The oral bioavailability of cefotaxime in nano-vesicles formulation after introduced to rats. DUPHAT Conference, 10th – 12th March 2013, Dubai, UEA

Teaching Courses

  1. Pharmaceutics I
  2. Pharmaceutics II
  3. Physical Pharmacy
  4. Medication Dispensing
  5. Pharmaceutical Calculation
  6. Industrial Pharmacy

Memberships

  1. A reviewer of  PLOS Neglected Tropical Diseases -Thomson Indexed International Journal, Impact Factor 4.35 (Public Library of Science) - USA
  2. Associate Editor of Advancements in Bioequivalence & Bioavailability Journal (Crimson Publishers, LLC) - Regus - New York, USA
  3. Member of American Association Pharmaceutical Scientists (AAPS).
  4. Editorial board member of SOJ Pharmacy & Pharmaceutical Sciences (Open Access American Journal) - Illinois USA
  5. Editorial board member Global Drug and Therapeutics (Open Access Journal) - London, UK
  6. A reviewer of Current Pharmacy Analysis (Bentham Science Publisher) - Netherlands 
  7. Editorial board member of Open Access Journal of Pharmaceutical Research (Open Access Journal) - USA 
  8. Editorial board member of EC Pharmacology and Toxicology journal (Open Access Journal) - UK
  9. Editorial board member of SOJ Pharmaceutical Sciences (Open Access American Journal) - Minden, NV, USA

  10. A reviewer of Current Drug Delivery -Thomson Indexed International Journal, Impact Factor 2.516 (Bentham Science Publisher) - Netherlands

  11. Editorial board member of Thermal Science and Engineering (EnPress Journal) - USA
  12. Peer Review Panel (PRP) Members for abstracts submitted to Controlled Release Society (CRS) 45th Annual Meeting and Exposition, New York, New York City (NYC), USA

  

ABSTRACTS

 

  • Mosab Arafat, Paul Fawcett, Ian G Tucker. The effect of bile salt content on the physical stability of bilosomesThe  Americana Association of Pharmaceutical Scientists Journal. 2009; 11 (S1). AAPS Annual Meeting and Exposition. Los Angeles, California, USA

 

  • Mosab Arafat, Paul Fawcett, Hu Zhang, Ian G Tucker. The oral bioavailability of cefotaxime in a bilosome formulation in rats. The Americana Association of Pharmaceutical Scientists Journal. 2011; 13 (S2). AAPS Annual Meeting and Exposition. San Francisco, California, USA

 

  • Mosab Arafat, Paul Fawcett, Ian G Tucker. The Influence of Physiological Media on The Stability of Bilosomes. The Americana Association of Pharmaceutical Scientists Journal; 2011; 13 (S2). AAPS Annual Meeting and Exposition.Washington DC, USA

 

  • Mosab Arafat, Paul Fawcett, Ian G Tucker. The influence of different media on the physical stability of different lipid-based vesicular systems. The Americana Association of Pharmaceutical Scientists Journal. 2011; 13 (S1). AAPS Annual Meeting and Exposition.Washington DC, USA

 

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