الموظفين

  • د. نادية حسين

د. نادية حسين

أستاذ مساعد

مقر العين

التعليم

  • Ph.D. Biomedical Sciences, College of Medicine and Health Sciences, UAE University, UAE
  • MBBS Baqai Medical University, Pakistan

الاهتمامات البحثية

Glutamate signalling pathway, diabetic neuropathy, pathogenesis of diabetic complications

منشورات مختارة

  • Hussain N, SA Said A, Baig M (2020), Levels of Vitamin D and Vitamin D pathway gene polymorphisms in adults: results based on rural agriculture workers in punjab province of Pakistan, Progress in Nutrition, Mattioli Health, Vol 22 No 2 (2020), DOI: 10.23751/pn.v22i2.8180, https://mattioli1885journals.com/index.php/progressinnutrition/article/view/8180
  • SA Said A, Hussain H (2020), Physicians’ and Pharmacists’ Perception and Practice of Hospital Pharmacist’ Professional Role in Egypt, International Journal of Pharmacy Practice, Wiley. DOI: 10.1111/ijpp.12638
  • Hussain, N., Said, A. S. A., & Khan, Z. (2020). Influence of Health Literacy on Medication Adherence Among Elderly Females with Type 2 Diabetes in Pakistan. International Quarterly of Community Health Education. DOI: https://doi.org/10.1177/0272684X19896724
  • Abu Mellal A, Hussain N, Said ASA, M A (2019), The Clinical Significance of Statins - Macrolides Interaction: Comprehensive Review of In vivo, Case-reports and Population Studies, Therapeutics and Clinical Risk Management, Dove press, 2019:15 Pages 921—936, DOI: 10.2147/TCRM.S214938
  • Hussain N, Said ASA, M A (2019), Mindfulness-Based Meditation Versus Progressive Relaxation Meditation: Impact on Chronic Pain in Older Female Patients With Diabetic Neuropathy. Journal of Evidence-Based Integrative Medicine. Vol 24, No 1 (2019) https://doi.org/10.1177/2515690X19876599
  • Hussain N, SA Said A, Khan Z (2018), Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia, International Journal of Breast Cancer, Volume 2018
  • Said A, Hussain N, Al Haddad AHI, Javid F. Effects of Alogliptin on hypertensive chronic kidney disease with Type 2 diabetes mellitus. AMJ 2018;11(2):113–123
  • Mahdy A, Hussain N, Al Khalidi D, SA Said A (2017), Knowledge, attitude, and practice analysis of corticosteroid use among patients: A study based in the United Arab Emirates (2017), Natl J Physiol Pharm Pharmacol. 2017; 7(6): 562-568
  • Hussain N (2015), Haemoglobin A1C and iron deficiency anaemia: our understanding thorugh the decades. Romanian Journal of Diabetes and metabolism 2015; 3 (22): 289–296
  • Hussain N (2015), Implications of using HbA1c as a diagnostic test for diabetes. Diabetology international journal (in press)
  • Hussain N, Adrian TE (2017), Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways. Current Diabetes Reviews 2017;13(5):488-497
  • SA Said A, Hussain N (2017), Adverse Drug Reaction Reporting Practices Among United Arab Emirates Pharmacists and Prescribers, Hospital Pharmacy. Vol 52, Issue 5, pp. 361 – 366

المواد التدريسية

Human anatomy and histology, Physiology, Pathophysiology, Science and Life, Immunology, Biology

 

أهداف التنمية المستدامة المرتبطة بالخبرات

في عام 2015 اتفقت الدول الأعضاء في الأمم المتحدة على 17 هدفًا للتنمية المستدامة لإنهاء الفقر، وحماية الكوكب، وضمان الرفاه للجميع.

تساهم خبرة هذه الشخصية في أهداف التنمية المستدامة التالية:

  

العضويات

  • Licensed medical physician, Pakistan medical and dental council, Pakistan
  • American Society of Physiologists, USA
  • American Physiology Society, USA
  • Emirates Diabetes Society, UAE
  • Emirates Medical Student Society, UAE

Levels of vitamin D and vitamin D pathway gene polymorphisms in adults: Results based on rural agriculture workers in Punjab province of Pakistan

أكتوبر 01, 2020

Hussain N Shaban A Baig M

Background and aims: Worldwide low levels of vitamin D (< 30ng/dL) is prevalent and linked to bone disorders, diabetes and coronary heart disease. Deficiency in Vitamin D is a diagnostic challenge in asymptomatic individuals. The present study aimed to assess the environmental and also the genetic determinants affecting vitamin D deficiency in an asymptomatic rural agricultural population sample of Punjab province of Pakistan. Material and method: An interview based questionnaire and blood samples for measuring serum markers were obtained. These include calcium levels, parathyroid hormone and serum 25(OH) vitamin D. DNA was extracted from the blood samples for genotyping. Results: From 510 study participants, 435 (85.2%) individuals had < 30 ng/dL (low) of vitamin D. Males versus females had a unremarkable difference in the status of Vitamin D (61.3% vs 56.2%), (p = 0.134). When calcium levels were compared between the deficiency and insufficiency groups versus the vitamin D sufficiency group, no significant difference was observed (p = 0.526, 0.155 respectively). Consumption of single milk serving every day (250 ml) (p = 0.818) and sunlight exposure every day for more than 30 minutes (p = 0.579) also had non-significant associations with the estimated vitamin D levels. However, oral vitamin D supplementation was significantly associated (p = 0.024) with the vitamin D levels. Eight SNPs were studied and none showed any statistical significant association with observed vitamin D levels. Conclusions: We noted a considerable proportion of asymptomatic individuals from the rural population with low vitamin D levels. There appear to be multifactorial causes of deficiency in vitamin D and this burgeoning health issue requires further investigations.


Influence of Health Literacy on Medication Adherence Among Elderly Females With Type 2 Diabetes in Pakistan

أكتوبر 01, 2020

Hussain N Shaban A Khan Z

Health literacy is how well the patients are able to attain, deal with, and understand basic health information. This is particularly important when it comes to comprehending prescribed medication instructions. To improve the communication strategies for health-care professionals during patient counseling, our study aimed to assess the influence of health literacy and medication adherence in older patients. The objectives of the study were to evaluate associations that occur between the level of health literacy and medication adherence. This study used a convenience sampling method of females (older than 60 years) attending the diabetic clinic in two hospital settings (N = 524). All study participants filled three validated questionnaires: these were the Literacy Assessment for Diabetes, the Diabetes Numeracy Test, and a modified Brief Adherence Rating Scale. To assess the spectrum of health literacy differences, we used χ2 analysis and linear regression analysis. Individuals with adequate health literacy were more likely to remember to take their medications compared with those with inadequate health literacy, χ2(4) = 11.6, p =.04. Adequate literacy level study participants were more likely to not change the dose of their medications without medical advice (12.3%) compared with those individuals with inadequate health literacy (2.8%), χ2(4) = 11.13, p =.03. The results in our study suggest that health-care professionals should focus on appropriate communication attuned to the assessment of health literacy levels particularly in older female patients when discussing medication instructions. © The Author(s) 2019.


Physicians’ and pharmacists’ perception and practice of hospital pharmacist professional role in Egypt

يونيو 01, 2020

Said A Hussain N Abdelaty LN

Objectives: This study aimed to investigate physicians’ and pharmacists’ perceptions of the importance of pharmacists’ role in healthcare in Egypt, and actual delivery of these roles in practice. Identifying any differences and inconsistencies between these will inform future strategies that maximize pharmacists’ professional contribution to hospital practice. Methods: A self-administered questionnaire using a 5-point Likert scale was distributed to a convenience sample of physicians (500) and pharmacists (500) practicing in selected private or public hospitals in Egypt. The main sections of the questionnaire comprised statements that pertained to physicians’/pharmacists’ views on the importance of pharmacists’ roles and their actual delivery in practice. Key findings: In this study, physicians showed low scores for both the importance of and the delivery of advanced patient-facing clinical pharmacy roles such as suggesting prescription medications, and designing treatment plans. In comparison, pharmacists were more positive on both of these aspects of their roles. High mean scores were reported by the physicians for pharmacist’s traditional roles such as patient counselling, assessing compliance, preventing medication errors and treating minor illnesses. Both physicians and pharmacists reported poor pharmacists practice as drug information resources despite their high perception of the importance of that role. Conclusion: This study suggested that in hospitals in Egypt, there are significant differences between physicians’ and pharmacists’ perception and practice, and pharmacists’ clinical skills are underutilized in health care. © 2020 Royal Pharmaceutical Society


Full-text Available

Effects of Alogliptin on hypertensive chronic kidney disease with Type 2 diabetes mellitus

مايو 03, 2018

/ Amira Shaaban / Nadia Hussain Farideh Javaid

Background: Diabetes mellitus(DM)is a leading cause of chronic kidney disease (CKD). Theantihyperglycemic treatment options for patients with Type 2 DM are limited because of safety and tolerability concerns. Aims: To retrospectively assess the effect of using Alogliptin; a dipeptidyl peptidase-4 inhibitor (DPP-4i) alongwith conventional gliclazide: a sulphonylurea (SU) on renal outcomes and glycaemiccontrol in T2DM patients with mildCKDand hypertension. Methods: A total of 76 patient records (38 males and 38 females) of patient ages 40–60 were analysed from the kidney unit at Punjab Care hospital, Lahore, Pakistan. All patients had a confirmed history of T2DM with mild CKD and established hypertension.Eligible patients were divided into two groups of 38 individuals each. Group SU received gliclazide monotherapy (SU) or Alogliptin (DPP-4i)+gliclazide (SU) add on therapy. All patients were followed up for 12 months.ResultsThe alogliptin (DPP-4i) plus gliclazide (SU) add on therapy group, in comparison to the group only receiving gliclazide (SU), showed a significant difference in eGFR values. The mean±SD GFR values post 12 months were 74.8±0.31(95%CI:74.8±0.09;74.7–74.9) and 76.1±0.25(95%CI: 76.1±0.08;76.0-76.2) for SU vs.SU+DPP-4i, respectively, with mean calculated effect size of 1.6,.HbA1c, 1,5 AG and ipid profile values have significantly changed(p<0.05) while blood pressure values showed no change. The mean±SD systolic blood pressure readings post 12 months for for SU vs.SU+DPP-4i were 131.4±10.4 (95% CI 131.4±3.3;128.1–134.7), and 131.8±9.9 (95%CI 131.8±3; 128.8–134.8), respectively. Conclusion: In the present study, patients using alogliptin in addition to sulfonyl urea showed improved glycaemic control and lipid profile without increased occurrence of hypoglycaemia. We concluded that, DPP-4iinhibitors are safe treatment options for patients with type 2 diabetes and mild degree of renal impairment.


Full-text Available

Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia

أبريل 19, 2018

/ Nadia Hussain / Amira Shaaban Zainab Khan

Abstract Aim. To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women with nonmetastatic HER2-positive breast cancer. HER2 overexpressed in 20–25% of breast cancer signals an aggressive form of breast cancer and is treated with trastuzumab and pertuzumab. Methods. The patient record database was accessed to identify all postmenopausal women in the Punjab Care hospital who were above 65 years old, with stages 1–3 HER2-positive breast cancer and treated with neoadjuvant TCHP and neoadjuvant TCP from 2013 till 2016. Results. In TCH-P group and TCH group, mild fatigue (34% versus 36%) and diarrhea (48% versus 49%) were most common toxicities. Fever in TCH-P group and TCH group (12% versus 13%) was common. Anorexia affected 21% and 16% of patients receiving TCH and TCHP regimen, respectively. Febrile neutropenia was higher in TCH-P group 13% (3/23) versus 4.5% (1/22) in TCH group. Also 27.2% (6/22) of TCH-P group was hospitalized for treatment related toxicities versus 21.7% (5/23) of TCH group. Conclusion. Comparing neoadjuvant TCP and neoadjuvant TCH-P showed TCH-P regimen had an acceptable toxicity profile. Severe cardiac dysfunction was not observed. Using TCH-P regimen can be considered as relatively safe therapeutic option for elderly postmenopausal women with nonmetastatic HER2-positive breast cancer.


Full-text Available

Knowledge, attitude, and practice analysis of corticosteroid use among patients: A study based in the United Arab Emirates

فبراير 09, 2017

/ Amira Shaaban Amina Mahdy / Nadia Hussain Doaa Khalidi

Background: Corticosteroids (CS) have long been known as the most powerful of all known anti-inflammatory agents. Since their introduction in 1949, they have shown pivotal role in the treatment of various serious disorders such as autoimmune diseases, allergic processes, organ transplantation, rheumatologic, dermatological, pulmonary, hematological, ophthalmologic, gastrointestinal disorders, and others. Nevertheless, such massive clinical use does not come without risks, where prolonged use has been linked to several serious side effects. Therefore, careful consideration of precautions recommended for safe use of CS is of paramount importance. Aims and Objectives: To assess knowledge, attitude, and practice (KAP) analysis of the proper use of different dosage forms of CS medications in different sets of CS users in the United Arab Emirates (UAE), to explore the extent to which steroid outpatients were well engaged with medication proper use and safety-related behaviors. Materials and Methods: A structured interview-based methodology was adopted to assess the KAPs revolving around steroid usage in patients located in the UAE cities; Dubai, Sharjah, Ajman and Al Ain. Patients (n = 250) were selected randomly from different outpatient clinics all over the previously designated cities. The prepared interview questions were selected based on related therapeutics guidelines regarding aspects of proper patients CS use. Data were collected by well-trained researchers to conduct such interviews. SPSS V16.0 (SPSS Inc., Chicago, USA) was used for data analysis. Standard descriptive and analytical statistics were used to analyze the data. StudentÂ’s t-test was used to compare the mean difference of continuous variables. Results: Overall, our study showed poor KAP results among different UAE patients using different CS dosage forms. Conclusion: Despite the massive use of CS in almost every clinical settings and its inherent associated risks, patients still needs provisions for better education regarding their medication efficacy, safety, and proper use. By careful follow-up of proper CS use instructions, both patients and physicians would positively reach an optimized cost-effective therapeutic approach with much more improved benefit/risk ratio.


حقوق الطبع والنشر © 2024 جامعة العين . جميع الحقوق محفوظة.